IRB Reliance Agreements

USC promotes and engages in agreements by which an IRB relies on the review conducted by another entity. There are various types of agreements and they vary in scope, terms, and terminology. These agreements are designed to reduce duplication of IRB review and increase efficiency.  Completion of the iStar submission form will assist in determining whether an agreement is needed.  Among the commonly used reliance agreements are:

  • IRB Authorization Agreement (IAA)
  • Memoranda of Understanding (MOU)
  • IRB Authorization Agreements (IRBAA)
  • Master Reliance Agreement (MRA)
  • Collaborative Review Agreement (CRA)
  • Ceded Review

For more information refer to HSPP Policy and Procedures

Agreements to which USC is a party:

About IRB Reliance Agreements

Single IRB Review (NIH Mandate)

In 2017 the NIH will begin enforcement of a policy on the use of a single Institutional Review Board (IRB) for multi-site research. A single IRB (sIRB) of record must be used in the review
of human subjects research protocols funded by the NIH that are carried out at more than one site in
the United States. The goal of the policy is to streamline the IRB review process and eliminate
duplicative IRB review without diminishing human subjects protections.