IRB Review Agreements

USC has established inter-institutional agreements to simplify the IRB review process.

Ceded Review Memoranda of Understanding (MOU)

The Ceded Review Memorandum of Understanding (MOU) allows one Institutional Review Board to rely on the IRB review conducted at another institution. This mechanism reduces duplication and increase efficiency by designating and establishing a single IRB review when more than one site is involved in a research project.

Review of human subject research under these MOU shall be conducted in accordance with all applicable federal, state, and local laws, statutes and regulations governing the protection of human subjects.

Collaborative Agreements for Review of Joint Research

Collaborative review is used when two or more institutions are engaged in a human subjects research project. One institution’s IRB is chosen to carry out the regulatory review while the other institution conducts an abbreviated facilitated review. Links to the agreements are included below:

USC and Rancho Los Amigos

 

Vanderbilt University IRBshare

USC is a signatory to IRBshare, a collaborative multisite IRB review model for qualified, FWA-holding IRBs within the CTSA Consortium to share both documents and in the IRB review process in order to reduce duplicative reviews. IRBshare runs on a centralized, secure web portal currently operated & maintained by Vanderbilt University.

Overview of IRBshare
IRBshare FAQs
https://irbshare.org/

National Cancer Institute’s Central IRB Initiative

Under the new model the NCI Central IRB will be the IRB of record for cooperative group protocols. The local PI and IRB will be responsible for supplying information related to local context.

USC IRB Authorization Agreement with NCI-CIRB
NCI CIRB website