Office for the Protection of Research Subjects

The Office for the Protection of Research Subjects (OPRS) is the administrative arm of USC’s Human Research Protection Program (HRPP). OPRS, in partnership with the research community, is responsible for ensuring the safety and welfare of participants in Human Subjects Research conducted under the aegis of USC. OPRS, which is a Division within the Office of Research, provides the campus and the four USC Institutional Review Boards (IRBs) with professional guidance and administrative support and oversight.

The IRB office will be closed 

November 16-19, 2021

Staff will be attending the

2021 Public Responsibility in Medicine and Research Conference

IRB Tip of the Week!

The new IRB submission guidelines went into effect on Monday, October 4, 2021. Protocols that do not adhere to these basic guidelines will be returned without review. We expect these guidelines to improve the quality of submissions as well as our ability to complete our reviews more effectively and efficiently. Please click here to view the IRB Submission Guidelines.


New Required Research HIPAA Course

USC researchers and staff who use or access protected health information will be required to complete the Research HIPAA course offered online through CITI when renewing certification for the Good

Office Closures

OPRS and IRB offices will be closed on the following dates: