About Office for the Protection of Research Subjects

The Office for the Protection of Research Subjects (OPRS) is the team at the core of USC’s Human Subjects Protection Program. While IRBs review projects involving human subjects research, OPRS develops program-wide policies for the conduct and review of human subject research at USC. In addition, OPRS provides educational and training resources, two newsletters (Human Subjects Research Newsletter, Clinical Research Coordinator Newsletter), maintains the OPRS/IRB website, offers in-person presentations for Research Coordinators, IRBs, and USC researchers.

OPRS  also conducts a wide ranging Continuous Quality Improvement (CQI) program to identify and implement efficiencies and best practices in submission, review, oversight and conduct of human subject research. An annual IRB satisfaction survey, and not- for-cause- audits are CQI activities as well.
Contact OPRS with your suggestions, complaints, requests for policy clarifications, education sessions, or questions about new requirements.

What We Do

Policies and Procedures

  • OPRS develops and maintains USC Human Subjects Research Policies and Procedures as standards and regulations evolve.
  • OPRS disseminates information on regulatory changes to the research community through education sessions, listservs, newsletters, and IRB meetings.


  • OPRS keeps the USC human subjects research community apprised of evolving practices and expectations.
  • Information is disseminated through the USC Human Subjects Newsletter, education sessions, lectures, and this website. Ongoing dialogue is maintained with USC schools, department faculty, staff, and students to address issues of mutual concern.


  • OPRS is committed to furthering education at all levels of the Human Subject Protection Program.
  • OPRS has implemented an education policy that requires all USC human subjects researchers to complete training in Human Subjects Protection regardless of the researchers’ funding source, or study risk-level.
  • OPRS offers regular and ongoing human subjects educational training sessions covering federal regulations, human subjects ethics and history, the Institutional Review Board process, conflicts of interest, and more.
  • OPRS provides IRB members with monthly education and refreshers in research regulations as needed.

Best Practices

  • OPRS is committed to best practices and the proper application of ethics and regulations.
  • Leading the HSPP team, OPRS coordinates and implements Federal, State, Local and University policies.
  • OPRS routinely performs policy revisions, quality improvement, and seeks to adopt new practices as needed.
  • OPRS oversees four IRBs to ensure that regulations, institutional polices, and USC’s Code of Ethics, are being upheld.
  • OPRS Executive Director and staff communicate with peers at other institutions and government offices in search of new and better ways to protect subjects and uphold local policy.

National Leadership

  • OPRS is proud to share its ideas and practices with the local, regional, and national human subjects research communities.
  • Educational materials and innovative practices created by OPRS have been implemented by many other research institutions.
  • OPRS Executive Director Julie Slayton regularly serves as a faculty and planning committee member at premier national conferences, is a writer and contributor to the CITI human subjects education program, and sits on the planning committee for the AAHRPP national conference.


OPRS office is committed to outreach beyond USC and promotes this in a variety of ways:

  • distributing educational brochures at USC affiliated hospitals and clinics
  • participating in health fairs and events
  • serving on USC community outreach committees and the CBLC (Community Based Learning Collaborative)
  • networking through IRB community members
  • volunteering at local schools and churches.


OPRS is committed to developing novel, effective, and innovative best practices. Some of these efforts include:

  • the placement of undergraduate students as voting members on the IRB
  • our publications and booklets have garnered national attention
  • bringing a greater focus to the community of USC Research Coordinators, particularly by starting the Research Coordinator Bulletin
  • the building and management of a comprehensive HSPP website which receives over a quarter million hits annually

Contact OPRS

The Office for the Protection of Research Subjects
3720 South Flower Street, Third Floor
(213) 821-1154

Julie Slayton, JD, PhD
(213) 821-1155

Katherine B. Hawthorne
Program Manager
(213) 821-4218

Ani Yessaian
Program Administrator
(213) 821-1154